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Pasireotide long-acting release (PAS-LAR) has also been reported to lower serum GLP-1 and GIP levels in phase 1 studies conducted on healthy volunteers 21

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While GLP-1 therapies are highly effective for weight management, they also introduce physiological changes beyond appetite control

As the half-life of retatrutide is 6 days, once weekly administration was sufficient with as expected gastrointestinal disturbance being the most common side effect and occurring in 63% of those on retatrutide, 60% on dulaglutide, and 54% of the placebo cohort [63]

Since many individuals with Hashimoto's experience weight gain and difficulty losing weight despite adequate thyroid hormone replacement, the appetite-suppressing properties of GLP-1 agonists may appear attractive