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You can return to work or daily activities immediately after treatment

Rodier, Exploiting interconnected synthetic lethal interactions between PARP inhibition and cancer cell reversible senescence

This is when: Most people think "okay, this is actually working." Month 4-6: Significant transformation Physical changes: 5-10 pounds lean muscle gain (cumulative) 15-25% strength increases across all lifts Substantial improvement in body composition Fat loss continues even while building muscle Muscle maturity - look more "filled out" What you'll notice: Completely different physique Clothes fit differently (tighter upper body, looser waist) Consistent comments from friends and family Training weights significantly higher than starting point Visible abs even if they weren't there before (if diet is decent) What photos show: This is where dramatic before and after photos come from

First the patients were from a single institution, and several had comorbidities

The full therapeutic effect often requires reaching an individualized effective dose, which varies by patient