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Acknowledgements This work was funded or supported by grants of the Deutsche Forschungsgemeinschaft, project number 209933838 (SFB1052 Obesity Mechanisms: A1 to MS, B1 to MB, B3 to PK, B4 to NK, B12 to KK, C7 to JTH, Z3 to MvB) and project number 652 530364326 (to KS)

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