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[DOI] [PubMed] [Google Scholar] 92.Ercal N., Gurer-Orhan H., Aykin-Burns N

Opioid-induced androgen deficiency is well-documented, and GH axis suppression is a co-occurring effect in long-term opioid users

Wu S, Qiu C, Ni J, Guo W, Song J, Yang X, et al

Remember berberine is not suitable for everyone and should not be used in pregnant, nursing or planning to become pregnant

In cardiovascular outcome trials (CVOTs) such as Empagliflozin Cardiovascular Outcome Event Trial in Type 2 diabetes Mellitus Patients (EMPA-REG OUTCOME), CANagliflozin cardioVascular Assessment Study (CANVAS) and The Dapagliflozin Effect on Cardiovascular EventsThrombolysis in Myocardial Infarction 58 (DECLARE-TIMI 58) [6], they reduced the onset and progression of DKD, which was confirmed in the dedicated kidney trial The Canagliflozin and Renal Endpoints in Diabetes with Established Nephropathy Clinical Evaluation (CREDENCE), which showed a canagliflozin-induced risk reduction for ESKD in people with DKD by 32% [7]