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2.3.1 Sweet and umami receptors (TAS1Rs) L and K cells in the intestine express taste receptors that sense luminal carbohydrates and amino acids, triggering secretion of gut hormones such as GLP-1 and GIP

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20 In mouse models, direct administration into the brain reduces food intake by altering the mesolimbic reward circuit and increases the firing rate of pro-opiomelanocortin neurons that regulate appetite

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