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The combined primary endpoint of death from cardiovascular disease, nonfatal myocardial infarction, or nonfatal stroke occurred in 569 (6.5%) of patients in the semaglutide group versus 701 (8.0%) of patients in the placebo group, yielding a significant hazard ratio of 0.8 for a 20% relative risk reduction

The researchers note that people previously treated with tirzepatide generally lost more total weight initially, which may partly explain the larger rebound

doi: 10.1210/jc.2003-030049 142 StonehouseAHHolcombeJHKendallDM

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