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Leydig cells are considered crucial for testosterone production

Since MTX induces oxidative stress by increasing reactive oxygen species in tissues (Reference Jahovic, Cevik and Sehirli38,Reference Moghadam, Tutunchi and Namvaran-Abbas-Abad40,Reference Olayinka, Ore and Adeyemo43) , the effects of various antioxidant substances against MTX-induced oxidative stress have been investigated (Reference Savran, Cicek and Doguc7,Reference Jahovic, Cevik and Sehirli38,Reference Olayinka, Ore and Adeyemo43Reference Yuksel, Yuksel and Yagmurca45)

S., Armbruster, R., Reddy, D., Baur, J

Jul 21;85 (14):1159-64 Figueroa JD, et al., (2015) Modification of Occupational Exposures on Bladder Cancer Risk by Common Genetic Polymorphisms

If youre instead replacing them, its likely an expensive try