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As the critical role of glutamine in TME continues to be unveiled, recent investigations have shifted their attention towards unraveling the intricate involvement of 6-diazo-5-oxo-L-norleucine (DON) in modulating tumor immunity [183]

In some embodiments, the percentage of active agent is varied between about 1% and about 95%, between about 5% and about 80%, between about 10% and about 60% or more of the weight or volume of the total pharmaceutical formulation

Clinical dosing typically ranges from 5 to 30 milliliters daily for 10 to 20 day courses, administered by injection

These assays included bacterial mutagenicity tests with Salmonella and E