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This idea has sparked debate [201]

The approval was supported by liver biopsybased histological assessments from the first 800 patients after 72 weeks of treatment: Primary Endpoint 1: Resolution of steatohepatitis with no worsening of liver fibrosis Semaglutide group: 62.9% achieved the endpoint Placebo group: 34.3% achieved the endpoint Primary Endpoint 2: Improvement in liver fibrosis with no worsening of steatohepatitis Semaglutide group: 36.8% achieved the endpoint Placebo group: 22.4% achieved the endpoint Figure 1

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doi: 10.1002/micr.30855 6 ChangDWDayanJGreeneAKMacDonaldJKMasiaJMehraraBet al