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10.1242/dev.202449 163 HamadM

H., Hong, S

While the main focus of current therapies is on reducing IOP to protect the optic nerve and preserve vision, the evolution of treatment strategies goes far beyond traditional pharmacotherapy

Astrocytes also play a crucial role in the neuroinflammatory environment by undergoing reactive gliosis, marked by increased glial fibrillary acidic protein (GFAP) expression, which can compromise the blood-retinal barrier and promote inflammation (149, 151)

Facial edema was noted in 2 patients (1 receiving OCG monotherapy and 1 receiving OCG plus UVB combination therapy), but symptoms resolved without treatment