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Your body is in a caloric deficit, but water retention, hormonal shifts, and glycogen changes can mask fat loss for 2 to 3 weeks

3 lazy GLP-1 meal formulas you can repeat all week 1

~6 days Half-Life (NEJM 2023) ~30 days Full Clearance (5 half-lives) 4-5 weeks Steady State Per Dose Once Weekly Dosing Interval Investigational Status Retatrutide is investigational and not FDA-approved as of April 2026

6 Alternatively, some patients may be prescribed sulfonylureas or thiazolidiniones to improve insulin secretion, but both of these treatment options are associated with an elevated risk of heart failure making them unsuitable for use in patients with cardiovascular disease

Wegovy became available in Australia in 2024 and is currently not listed on the PBS for obesity, meaning patients pay the full cost out of pocket