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224 Analysis of scRNA-seq and spatial transcriptomics data from paired primary breast cancer tumors and lymph node metastatic tissues revealed that the process of lymph node metastasis in breast cancer involves a metabolic shift from glycolysis to oxidative phosphorylation and back to glycolysis, indicating a potential target for the treatment of tumor metastasis

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Early cytoskeletal protein modifications precede overt structural degeneration in the DBA/2J mouse model of glaucoma

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CONCLUSION This real-world analysis demonstrates high adherence rates to GLP-1 receptor agonists within a structured, digitally based weight management programme