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Ozempic NAION risks may be due to: Blood pressure and blood vessel effects : GLP-1 medications are known to lower blood pressure and influence how blood vessels regulate flow, which may contribute to reduced circulation in an already vulnerable optic nerve, according to the Asia-Pacific Journal of Ophthalmology

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Adding external GLP-1either through IV at high doses or as medicationslows down stomach emptying quite a bit

Scientific Background Growth hormone release is regulated through complex endocrine signaling involving hypothalamic and pituitary pathways

15,276 The activation of GLP-1R is linked to decreased NF-B pathway activity Treatment with GLP-1RAs can effectively mitigate chondrocyte apoptosis caused by endoplasmic reticulum stress and alleviate the associated inflammatory response