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PageMJMcKenzieJEBossuytPMBoutronIHoffmannTCMulrowCDet alUpdating guidance for reporting systematic reviews: Development of the PRISMA 2020 statement

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Who benefits most: Patients with blunted GnRH pulsatility, hypothalamic hypogonadism, low LH/FSH relative to low sex hormones, or desire deficit that persists despite adequate testosterone or estrogen levels suggesting the upstream neural cascade, not just the hormonal level, requires support