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This can happen for various reasons, such as when a doctor believes the medication may benefit a particular patient's condition, even though it hasn't been officially tested and approved for that specific use

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Data are presented as mean SEM with three independent biological repeats for each group

Indeed, a recent review highlights a potential signaling cascade involving NF-B, p38 and nitric oxide in which cannabinoids prevent the release of glutamate from hemichannels (Labra et al., 2018)