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However, avoid combining with strong acids like retinol or AHAs initially, as this can increase irritation risk

When laminar shear stress is perturbed at curved sections of arteries, the bioavailability of NO decreases, leading to an increase of the O2 - levels (Reference Hosoya, Maruyama and Kang86) and a decrease of Nrf2-activated genes, which results in a predisposition of the endothelium to atherogenesis (Reference Cheng, Siow and Mann87)

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