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In the UK, NICE technology appraisals (TA875 for semaglutide and TA664 for liraglutide) restrict these medications to specialist weight management services with specific eligibility criteria and time-limited treatment courses

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To enhance the cell permeability of RT, we converted the carboxylic acid groups to acetoxymethyl (AM) esters, which are readily hydrolysed by esterases to regenerate RT inside cells

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Hepatic Med