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MRS studies in LLD showed lower posterior cingulate N-acetylaspartate and decreased posterior cingulate glutamate and increased glutathione with citalopram treatment [189]

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However, novel dual receptor agonists have been developed for the treatment of obesity and T2D under the concept that GLP-1 restrains the hyperglycemic action of glucagon, while allowing it to exert its beneficial actions on bodyweight, food intake, lipid metabolism and thermogenesis (71)