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According to NICE guidance (TA875 and TA664), GLP-1 receptor agonists for weight management are typically initiated and supervised by specialist weight management services, with treatment duration limits (up to 2 years for semaglutide) and specific continuation criteria

This is due to extensive spread of atypical melanocytes beyond the visible margin of the lesion in some cases

Constipation Slowed gastric motility affects bowel function in some people

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