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By contrast, the flexibility of this helix in the postfusion conformation might contribute to the observed, much lower, binding affinity and occupancy differences (Extended Data Fig

Glutathione is the most abundant intracellular antioxidant and the backbone of natural defenses against reactive oxygen species, which are byproducts of normal oxygen metabolism that accumulate in the body with age and interfere with chemical processes

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H., Tan, K

Unlike ulcerative colitis, which is limited to the colonic mucosa, Crohns disease features skip lesions areas of diseased bowel separated by segments of normal-appearing tissue and may involve multiple layers of the intestinal wall, leading to fibrosis, stricture formation, and fistulization, as described by the Crohns & Colitis Foundation