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According to our current understanding of GLP-1RAs mitochondrial regulatory effect and oxidative stress suppression ability on eye diseases, the molecular pathways mainly involve the PINK1/Parkin-mediated mitophagy pathway and the GLP-1R-ERK1/2-HDAC6 signaling pathway (see Figure 3)

Furthermore, the transcript levels of Gcg and Ffar2 increased following IL-22 treatment in STC-1 cells (Supplementary Fig 12a)

Moreover, Semaglutide slows gastric emptying, which contributes to a reduced appetite and can lead to weight loss, an essential aspect of managing type 2 diabetes

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