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One subsequent analysis has estimated that 7.9 million individuals meet the SELECT trial criteria in the US: Among these individuals, treatment with semaglutide could prevent about 190 000 cardiovascular events in 5 years. If each eligible patient received semaglutide at a retail price of $16 188 per year, the total cost would amount to $127 billion per year. The authors of SELECT noted that: Potentially less costly alternatives for reducing obesity and CVD risk include lifestyle counseling, dietary fasting, and alternative pharmacological weight loss approaches

Int J Mol Sci 23:1 Cowen PJ, Parry-Billings M, Newsholme EA (1989) Decreased plasma tryptophan levels in major depression

Yes, under supervision

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