In addition, while molecular docking provided mechanistic insights, in vitro validation of the proposed SIRT1-mediated pathways was not performed
The supernatant of tumor cells treated with Ru(II)-OH, NP2, and NP4 was co-cultured with RAW264.7 macrophages, and the intracellular calcium levels in macrophages were evaluated (Fig
Jelovac N, Sikiric P, Rucman R, Petek M, Marovic A, Perovic D, Seiwerth S, Mise S, Turkovic B, Dodig G, Miklic P, Buljat G, Prkacin I
A decrease in the expression of the pro-ferroptotic proteins ACSL4, TFR1, and VDAC2/3 and a decrease in dihydroethidium (DHE) fluorescence, iron, malondialdehyde (MDA), and myeloperoxidase (MPO) were further observed in metformin-treated mice
Understanding this interaction is key to answering whether taking glutathione while drinking alcohol is beneficial or counterproductive