Moreover, periostin, which is primarily secreted by cardiac fibroblasts after myocardial infarction 88 , has been shown to induce cardiomyocyte cell cycle reentry and mitosis, and was associated with improved ventricular remodeling and myocardial function, reduced fibrosis and infarct size, and increased angiogenesis after myocardial infarction in mice 89
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They may recommend stopping treatment, especially if youre at risk of dehydration or severe constipation