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Increasing fiber intake can help support: Regular bowel movements Gut health Blood sugar control Cholesterol management Satiety Recommended Fiber Intake Adults should aim for: 25-35 grams of fiber per day Increase fiber gradually and make sure to increase water intake at the same time

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In Scenario 1, the patient has chronic depletion of carnitine stores

Phase 2 (Q1 2026) will add additional samples (up to 25,000 patients) and more detailed clinical phenotype data to identify predictive safety and tolerability markers and include further validation and refinement of the efficacy signals including: Phasing of drug therapy and impact on efficacy Prediction of high rebound cohorts Evaluation of potential efficacy in other indications PrecisionLife has developed and validated a world-leading combinatorial analytics platform to identify the drivers underpinning over 60 complex chronic diseases

These important findings suggest that tesofensine could be a safe and effective option for treating obesity