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More recently, endoplasmic reticulum stress-regulating neurotrophic factors such as mesencephalic astrocyte-derived neurotrophic factor (MANF) and cerebral dopamine neurotrophic factor (CDNF) have emerged as promising agents

A loading phase of 4 to 6 weeks at the higher end of the range is common, followed by a maintenance dose of 1 mg/day three to five times per week

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Overweight/obese MAFLD patients showed significant lower resistance and reactance levels (p0.05)

The experimental setup is described in more detail in Kogelheide et al