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For example, type 2 diabetes increases FA uptake and oxidation in the heart (Rijzewijk et al., 2009), high salt-induced cardiac hypertrophy was associated with no changes in FA metabolism ( FABP3 , which mediates FA transmembrane trafficking, was downregulated, while CPT1 , which mediates mitochondrial transport and -oxidation, was upregulated

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A single administration of CRISPR/Cas9 lipid nanoparticles achieves robust and persistent in vivo genome editing