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Mitochondrial iron accumulation further disrupts redox homeostasis, amplifying oxidative stress and contributing to persistent cellular injury (92)

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As for most other enzymes of the pathway, SIR may be persulfidated, but neither the cysteine affected nor the effect on activity have been explored (Figure 2 and Supplementary Table 2)

Cellular detoxification is broken into three phases, and glutathione enhances these stages of detoxification in many ways: Phase I (toxin modification) Toxins are detected within the cell and modified through oxidation and reduction reactions into forms the body can target

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