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CD5 and IL-2 are both involved in the functions of the immune system, while MMP2 is considered to play a role in the maintenance of extracellular matrix in tendons, skin, and other connective tissue

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In most diseases, ROS appear to have a direct connection with inflammaging and cell senescence, and oxidative stress and inflammaging increase the aging-related phenotype, and induce and aggravate the inflammatory response, creating a chronic state of systemic inflammation (290297)

The IMPACT MASH trial tested 1.2 mg and 1.8 mg doses over 24 weeks