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Long-acting gut-hormone agonists as a class tend to show tachyphylaxis of the gastric-emptying effect it attenuates with continued dosing even as central appetite suppression persists

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527,528 Bortezomib treatment reduces microvessel density in multiple myeloma patients, which is positively associated with improved prognosis, 529 indicating that antiangiogenic activity may serve as a prognostic marker for assessing the therapeutic outcomes of bortezomib