When combined with increased physical activity and a low-calorie diet, semaglutide (Wegovy) is indicated for weight management in patients with: Obesity (BMI of 30 kg/m or higher) Overweight (BMI of 27 kg/m or higher) with at least one weight-related health condition such as high cholesterol levels, hypertension (high blood pressure), heart disease, and type 2 diabetes Mechanism of action Semaglutide is a GLP-1 agonist that slows digestion, reduces appetite, and stabilizes blood sugar by working in the following ways: It mimics the action of glucagon-like peptide-1 in the lateral hypothalamus (hunger control centre), which suppresses appetite and gives you a feeling of satiety
The molecule is eventually metabolized through the breakdown of its peptide backbone and is eliminated via both urine and feces
Science 340 , 991994 (2013)
And dont worry, well unpack everything about semaglutide and menopause, including how the drug works, possible side effects, and why its becoming increasingly popular in the midlife women demographic
DOI: 10.1016/S0981-9428(02)01455-9 33
