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PCR of wild type allele and targeted allele result in ~1,500bp and ~800bp bands, respectively (left)

Importantly, proteolytic cleavage of SPARC (secreted protein acidic and rich in cysteine), a matricellular protein abundantly expressed at sites of vascular injury and tissue remodeling, generates GHK-containing fragments that promote endothelial cell proliferation and neovascularization

Without adequate blood flow, two problems can occur simultaneously: Oxygen depletion: Muscle tissue is deprived of the oxygen it needs to repair itself

doi: 10.1016/j.neuron.2009.06.026 176 KimJ.YooI