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Notably, the phase 3 ESSENCE trial, not included in the present algorithm because it was published after 31 January, 2025, showed that semaglutide was associated with a significant improvement in MASH and liver fibrosis 11 similar to tirzepatide

Obesity is linked to a wide range of health conditions, including heart disease, diabetes, cancer, and stroke

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A greater understanding of the mechanisms responsible for the clinical and metabolic effects of the poly-agonists, the balance of receptor agonism needed for optimal effects, and the heterogeneity in response among individual patients and different patient populations will be important to guide future drug development and clinical application