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Finally, the pleiotropy-original sin hypothesis postulates that cell death is an immanent and inevitable process associated with the formation of metabolic by-products in cells like reactive oxygen species (ROS) and cell death machinery components-encoding genes were not initially related to cell death processes and performed pro-survival functions

Liver size is governed both by genetic factors and by the rate of biochemical activity to maintain optimal functional mass

Since 90% of the bodys serotonin originates in the gut, modulating enteric serotonin production could influence central serotonergic tone through vagal afferents that relay gut signals to brain serotonin-producing raphe nuclei

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