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Approximately equal numbers of patients were randomized to receive initial therapy with 100 mg of sitagliptin in combination with 30 mg of pioglitazone once daily or 30 mg of pioglitazone once daily as monotherapy

At physiological concentrations, ROS play important functions in cells, including participating in intra- and intercellular signal transduction as well as exerting toxic effects on phagocytosed bacteria, parasites and tumor cells (Gob et al., 2002)

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Finally, early research suggests GLP-1 drugs might also have protective effects in diseases like Alzheimers and Parkinsons, but further investigation is required