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(2018) 93:E1757

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The most common side effects of NAC include: Upset stomach Nausea or throwing up Diarrhea Fatigue Eye irritation Itching or rash Skin swelling Wheezing Less commonly, NAC may cause: Low blood pressure Increased asthma symptoms Chest tightness or numbness around your mouth (if you inhale it) Headache Life-threatening allergic reaction (anaphylactic shock) Other considerations for N-acetylcysteine NAC may also: Slow blood clotting

More recently, emerging MRI techniques aimed at directly estimating extracellular pH have further expanded the potential to non-invasively characterise tumour acidity (194, 195), although these remain largely in the early stages of clinical validation

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