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An intelligent nanomachine guided by DNAzyme logic system for precise chemodynamic therapy

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Stomach acid and various digestive enzymes in the gastrointestinal tract may degrade glutathione, resulting in its lower bioavailability

Journal of Alternative and Complementary Medicine, 17 (9), 827833.

Particularly insightful mechanistic evidence comes from a medaka fish NAFLD model, where metabolomic analysis revealed that L-carnitine not only reduced hepatic lipid deposition but also significantly elevated hepatic -oxidation end products (acetyl-CoA and ATP) while upregulating antioxidant enzyme superoxide dismutase 2 (SOD2) (35)