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doi: 10.3389/fnagi.2025.1667448 Received 16 July 2025 Accepted 11 September 2025 Published 01 October 2025 Volume 17 - 2025 Edited by R

Reduce appetite and food intake : GLP-1 drugs like Wegovy act on areas of the brain that regulate appetite and food intake

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Corroborating a functional role of GIPR, GLP-1GIPLani decreased body weight and food intake with increased efficacy compared with GLP-1Lani, but with equal efficacy to co-therapy of GLP-1Lani and a long-acting GIPR agonist (acyl-GIP) (Fig

Evaluate Delivery Method: If systemic absorption is key, prioritize enteric-coated capsules