There is evidence to suggest that mutations in the MAGEL2 gene may contribute to the characteristic weight gain seen in individuals with PWS
Design of in vivo Experiments The animals were separated into 4 groups according to the treatment schedule, as follows: saline (saline 0.9% + cecal ligation and puncture CLP/ n = 18 animals), Ceftriaxone (Cef 20 mg/kg + CLP/ n = 6 animals), aqueous extract of Ab (Ab 135 mg/kg + CLP, n = 18 animals) and sham (surgery control, n = 18 animals)
Web Page, NCD RisC, accessed May 2024
Age, sex, and genetic factors may also influence response, though these were not primary endpoints in early studies
Either way, hair loss on these drugs tracks with how fast you lose weight, not with the drug itself