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The ATG16L1 complex then induces the formation of ER-derived non-canonical autophagosomes containing activated STING

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Over time, that mechanical load accelerates cartilage breakdown, worsens inflammation, and drives the kind of persistent joint pain that becomes a daily reality for many people with obesity

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Following transduction with an adenovirus carrying the NPY-mCherry construct for 72 h, we induced glucagon granule exocytosis using a combination of 1 mM glucose and 10 M adrenaline