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Similarly, CPUY192018, a potent small-molecule inhibitor of the Keap1-Nrf2 PPI, demonstrated cytoprotective effects in NCM460 colonic cells and a DSS-induced UC model by activating Nrf2 signaling (262)

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Given the role of TR in proper photoreceptor development, decreased thrb expression may contribute to altered photoreceptor a-wave responses we observed in adult ERGs from this treatment group

[1] [2] NAD+ also acts as a precursor for cyclic ADP ribose, a secondary messenger molecule crucial for calcium transmission