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Further trials are needed to investigate whether GLP-1 agonists, and particularly with more effective weekly agents (i.e

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7d), surpassing the reduction observed in the other groups

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Tirzepatide in 2026 While semaglutide targets the GLP-1 receptor exclusively, tirzepatide activates both GLP-1 and GIP receptorsa dual-agonist mechanism showing slightly higher average weight loss (21-23%) in head-to-head comparisons