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Joint Bone Spine

Glucagon-like peptide-1 receptor agonists (GLP-1 RAs), initially developed for type 2 diabetes and later approved for obesity, are now being explored for their broader applicability across this heterogeneous clinical population [20]

Presently the combination of a non-bile acid FXR agonist (GS-9674) + ACC inhibitor (GS-0976) is being investigated in an early phase II clinical trial.103 In an animal model of NASH, treatment with this combination therapy demonstrated a greater reduction in hepatic steatosis and genes associated with fibrosis than treatment with either agent alone.104 Future clinical trials will likely use combinations of agents that have already produced positive results individually

Obesity remodels activity and transcriptional state of a lateral hypothalamic brake on feeding

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