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This breakdown of the BBB coincided with extensive microglial activation, dopaminergic neuronal degeneration, and upregulation of P-glycoprotein and 3-integrinchanges suggestive of a compensatory and potentially angiogenic response

Multiple liver transplant cases documented at supratherapeutic doses (6-9 grams/day) with fetal death

Feb 2011;185(2):719-724

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doi: 10.1007/s11033-020-05590-5 Summary Keywords antidepressant effects, Ashwagandha, depressive disorder, Rhodiola, supplements Citation Li X, Li X, Li Y, Liu Z, Cai Y, Yao Q, Zhao S and Yu Q (2026) Rhodiola rosea , Ginkgo biloba , and Ashwagandha as novel antidepressant supplements: converging monoaminergic, neurotrophic, anti-inflammatory, and brain health pathways in depressive disorders