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Instruct patients to contact their healthcare provider if they have severe or persistent gastrointestinal symptoms [see Warnings and Precautions ( 5.6 )]

To give you an idea of the sensitivity in the model, every 1% change in our year-over-year price erosion forecasts has a $6 billion impact on our US peak sales numbers

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Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required