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OxS is usually defined as Sa physiologically significant alteration in redox status resulting from an overproduction of reactive oxygen species (ROS) and/or a deficiency in antioxidant protective mechanisms [6]

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The figure also shows that the selenium-dependent enzyme glutathione peroxidase oxidizes two molecules of glutathione back to GSSG while converting one molecule of hydrogen peroxide (H 2 O 2 ) into two molecules of water (H 2 O)