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Certain health conditions such as intestinal or stomach problems, poor nutrition, cancer, HIV, pregnancy, old age, veganism and alcoholism can cause vitamin B12 deficiency

Many peptides cause hormones to be secreted from endocrine glands

Your hydration levels, activity level, and overall metabolic health also play a role in how quickly you notice the benefits

Determining what qualifies as medically necessary, however, can get complicated

Notably, gene-expression studies have associated GHK-Cu with the modulation of thousands of genes tied to tissue remodeling and the inflammatory response, which is why it is studied as a foundational signal peptide in repair models