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They may also be preferred in patients with elevated glycemia levels and high BMI aiming at modifying CV risk factors (2)

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GLP-1 can stimulate islet cells to secrete insulin and inhibit glucagon secretion ( Cholesterol efflux has long been regarded as a critical mechanism of maintaining intracellular cholesterol homeostasis, which could be primarily regulated by the LXR transcription factors and their targeted genes, the ATP-binding cassette (ABC) cholesterol transporters ABCA1 and ABCG1 ( Inflammation has been implicated in the pathophysiology of type 2 diabetes ( As mentioned previously, PARP1 synthesizes PAR for PARylation of both itself and other proteins (nuclear and cytoplasmic) using NAD+ and ATP, leading to the activation of transcription factors such as NF-B and AP-1 ( A previous study has revealed that PARP-1 could inhibit LXR-induced ABCA1 expression and cholesterol efflux from macrophages ( Bariatric surgery can significantly alleviate T2DM and usually can substantially improve blood glucose levels prior to weight loss after surgery ( Conclusion GLP-1 inhibits PARP-1 to protect islet cell function against cholesterol-induced toxicity in vitro and in vivo through the enhancement of cholesterol efflux