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Why This Matters More Than Trial DXA Data The SURMOUNT and STEP DXA substudies that established the "25-30% of weight loss is lean mass" baseline were done in trial populations: motivated patients, structured visits, baseline DXA, often dietitian contact

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Patients with pre-existing insulin resistance or type 2 diabetes need fasting glucose and HbA1c monitoring before starting and every 8-12 weeks during a cycle

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