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Hentze MW, Muckenthaler MU, Andrews NC

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Heavy metals are found in foods, medicines, via industrial exposure, lead-based paints, by the ingestion of pesticides, herbicides, and insecticides

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However, there is increasing experimental and clinical evidence for interactions between abnormal DA metabolism and mitochondrial defects in schizophrenia, which has more complex and diverse clinical manifestations in categories of positive symptoms, negative symptoms, and cognitive impairment